Study on the stability of microcrystalline chitosan systems with selected non-steroidal anti-inflammatory drugs

K.H. Bodek

Published : 2022-09-01

Vol. 49 No. 1 (2004)

Study on the stability of microcrystalline chitosan systems with selected non-steroidal anti-inflammatory drugs

K.H. Bodek

Abstract

The stabilities of microcrystalline chitosan (MCCh) systems with selected non-steroidal anti-inflammatory drugs (NSAIDs) were investigated after storage at ambient temperature for 12 months or at 60 and 80 °C for 5 h. Diclofenac (DA) and ketoprofen (KTA) in free acid form were used as model drugs in this study. For both the MCCh-drug (DA, KTA) systems, the intensity of bands corresponding to chitosan and drug slightly decreased as the temperature increased. X-ray diffraction and differential scanning calorimetry (DSC) showed that KTA in the microcrystalline chitosan systems remained in the amorphous state in contrary to DA, which was present in crystalline state. The interactions between DA and MCCh are not as strong and develop with time. The interaction between KTA and polymer (decrease in drug crystallnity) in stored systems is similar to those in freshly prepared samples. The amorphic form of KTA is present throughout the whole storage time. Slight decrease in KTA release rate was observed for MCCh film stored at 80 °C. These results suggest that microcrystalline chitosan is a suitable carrier for drugs of different solubility.

Keywords

chitozan mikrokrystaliczny ; substancje przeciwzapalne ; substancje niesteroidowe ; nośnik leku ; szybkość uwalniania ; czas przechowywania ; wpływ temperatury microcrystalline chitosan ; non-steroidal anti-inflammatory drugs ; drug carrier ; storage time ; temperature effect ; release rate

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Bodek, K. (2022). Study on the stability of microcrystalline chitosan systems with selected non-steroidal anti-inflammatory drugs. Polimery, 49(1), 29–35. Retrieved from https://polimery.ichp.vot.pl/index.php/p/article/view/1722

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