Związki powierzchniowo czynne z grupy polioksyetylenowanych estrów kwasów tłuszczowych. Cz. I. Równowaga hydrofilowo-lipofilowa (hlb) i parametr rozpuszczalności a typ aktywności powierzchniowej produktów oksyetylenowania estrów metylowych kwasów tłuszcz

M. M. Zgoda; W. Hreczuch; M. Woskowicz; M. Nachajski; M. Kołodziejczyk

Published : 2022-09-17

Vol. 48 No. 5 (2003)

Surfactants from the group of fatty acids polyoxyethylenated esters. Part I. Hydrophylic-lipophilic equilibrium (HLB), solubility parameter and a type of surface activity of the rape oil fatty acids methyl esters oxyethylenation products

M. M. Zgoda W. Hreczuch M. Woskowicz M. Nachajski M. Kołodziejczyk

Abstract

Possibility of the application of domestic surfactants (ZPC) from the "Rofam" series (oleic acid oxyethylenated methyl esters) in a drug form technology has been investigated. The real mean number of oxyethylene units ((n) over bar (TE)), measured by H-1 NMR, has been used to determine the analytical level of hydrophylic-lipophylic equilibrium (HLB, H/L). The number of oxyethylene units in the,Rofam" homologous series, declared by producer (n(TE)*) as well as experimentally found (n(TE)), made possible verification of their molecular weights (M* and M, respectively) and calculation of the topological indices (SigmaIC and SigmaSIC), solubility parameters (delta* i delta) and structural level of hydrophylic-lipophylic equilibrium (HLB), using methods by Griffin or Davies, as well as HLBR (required HLB value) and H/L. Dependences between the number of oxyethylenated units in the "Rofam" structure and HLB, H/L and the topological indices (SigmaIC and SigmaSIC) have been described using correlation equations. It was demonstrated that the values of structural and analytical HLB levels are similar what makes the experimental evaluation of HLB value of chosen ZPC possible. This let estimate of ZPC practical usability. "Rofam" products characterized with n(TE) greater than or equal to8 showed the best functional properties from the pharmaceutical point of view, as transdermal transition promotors, solubilizers and emulsifiers of oil/water type.

Keywords

niejonowe związki powierzchniowo czynne ; szereg homologiczny Rofamów ; analiza metodą 1H NMR ; równowaga hydrofilowo-lipofilowa ; indeksy topologiczne ; parametr rozpuszczalności nonionic surfactants ; Rofam homologous series ; H-1 NMR analysis ; hydrophylic-lipophylic equilibrium ; topological indices ; solubility parameter

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Zgoda, M. M., Hreczuch, W., Woskowicz, M., Nachajski, M., & Kołodziejczyk, M. (2022). Surfactants from the group of fatty acids polyoxyethylenated esters. Part I. Hydrophylic-lipophilic equilibrium (HLB), solubility parameter and a type of surface activity of the rape oil fatty acids methyl esters oxyethylenation products. Polimery, 48(5), 365–370. Retrieved from https://polimery.ichp.vot.pl/index.php/p/article/view/1873

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M. M. Zgoda mkolodziejczyk@pharm.am.lodz.pl

Affiliation
Uniwersytet Medyczny, Katedra Farmacji Stosowanej, Zakład Technologii Postaci Leku, ul. Muszyńskiego 1, 90-151 Łódź, Poland, Instytut Ciężkiej Syntezy Organicznej Blachownia, Kedzieezyn-Koźle, Poland

W. Hreczuch

M. Woskowicz

M. Nachajski

M. Kołodziejczyk