Published : 2024-09-10

Stabilization of poloxamine and poloxamer block copolymer complexes in chlorinated organic solvents – mathematical modelling

Abstract

To develop a mathematical model describing the behavior of chromophore complexes, the main factors influencing the stability of poloxamine and poloxamer complexes were determined. Gel permeation chromatography, ultraviolet absorbance measurements and FT-IR were used for the analysis. It was found that the studied complexes in chlorinated organic solvents are unstable in the presence
of oxygen, air, or water. The developed mathematical model allows for more effective planning and execution of experiments due to the possibility of predicting UV absorption based on the distribution of complexes in chlorinated solvents.



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Alhanbali, O. A., Al-Shukri, S. M. ., Dardas, A. K. Y. ., Jaradat, N. A. ., Shraim, N. Y. ., & Arafat, M. . (2024). Stabilization of poloxamine and poloxamer block copolymer complexes in chlorinated organic solvents – mathematical modelling. Polimery, 69(9), 475–483. https://doi.org/10.14314/polimery.2024.9.1