Glycopolyoxazoline-lectin interactions. Effects of ligand structure on clustering kinetics

C. Diehl; H. Schlaad

Published : 2013-09-30

Vol. 58 No. 9 (2013)

Glycopolyoxazoline-lectin interactions. Effects of ligand structure on clustering kinetics

C. Diehl H. Schlaad

Abstract

Turbidimetric measurements were used to examine the clustering of concanavalin A (Con A) with glucosylated polyoxazolines. For homopolymers, and also block copolymers, precipitation of Con Aoccured faster with longer glucoslyated chains and higher valency of the ligand. For statistical copolymers, the same trend was observed for increasing spacing between glucose residues or decreasing epitope density. Also the nature of the non-binding side chains appeared to have impact on the clustering kinetics.

Keywords

polioksazolina ; glikopolimer ; lektyna ; kinetyka tworzenia klastrów polyoxazoline ; glycopolymer ; lectin ; clustering kinetics

Details

References

Statistics

Authors

Download files

PDF

Zasady cytowania

Diehl, C., & Schlaad, H. (2013). Glycopolyoxazoline-lectin interactions. Effects of ligand structure on clustering kinetics. Polimery, 58(9), 650–653. Retrieved from https://polimery.ichp.vot.pl/index.php/p/article/view/772

References

Kiessling L. L., Pohl N. L.: Chem. Biol. 1996, 3, 71.

2. Ambrosi M., Cameron N. R., Davis B. G.: Org. Biomol. Chem. 2005, 3, 1593.

3. Lundquist J. J., Toone E. J.: Chem. Rev. 2002, 102, 555.

4. Gestwicki J. E., Kiessling L. L.: Nature 2002, 415, 81.

5. Ooya T., Eguchi M., Yui N.: J. Am. Chem. Soc. 2003, 125, 13016.

6. Page D., Aravind S., Roy R.: Chem. Commun. 1996, 1913.

7. Page D., Roy R.: Bioconjugate Chem. 1997, 8, 714.

8. Page D., Zanini D., Roy R.: Bioorg. Med. Chem. 1996, 4, 1949.

9. Kelly T. L., Lam M. C. W., Wolf M. O.: Bioconjugate Chem. 2006, 17, 575.

10. Bae W.-S., Urban M. W.: Biomacromolecules 2006, 7, 1156.

11. Kitano H., Nakada H., Mizukami K.: Colloids Surf. B 2008, 61, 17.

12. Gu W. F., Chen G. J., Stenzel M. H.: J. Polym. Sci. Part A: Polym. Chem. 2009, 47, 5550.

13. Diehl C., Schlaad H.: Chem. Eur. J. 2009, 15, 11469.

14. Becer C. R.: Macromol. Rapid Commun. 2012, 33, 742.

15. Gestwicki J. E., Cairo C. W., Strong L. E., Oetjen K. A., Kiessling L. L.: J. Am. Chem. Soc. 2002, 124, 14922.

16. Cairo C.W., Gestwicki J. E., Kanai M., Kiessling L. L.: J. Am. Chem. Soc. 2002, 124, 1615.

17. Ladmiral V., Mantovani G., Clarkson G. J., Cauet S., Irwin J. L., Haddleton D. M.: J. Am. Chem. Soc. 2006, 128, 4823.

18. Miura Y., Koketsu D., Kobayashi K.: Polym. Adv. Technol. 2007, 18, 647.

19. Adams N., Schubert U. S.: Adv. Drug Delivery Rev. 2007, 59, 1504.

20. Hoogenboom R.: Angew. Chem. Int. Ed. 2009, 48, 7978.

21. Schlaad H., Diehl C., Gress A., Meyer M., Demirel A. L., Nur Y., Bertin A.: Macromol. Rapid Commun. 2010, 31, 511.

22. Hoogenboom R., Schlaad H.: Polymers 2011, 3, 467.

23. Kempe K., Weber C., Babiuch K., Gottschaldt M., Hoogenboom R., Schubert U. S.: Biomacromolecules 2011, 12, 2591.

24. Gress A., Völkel, A., Schlaad H.: Macromolecules 2007, 40, 7928.

25. Diehl C., Schlaad H.: Macromol. Biosci. 2009, 9, 157.

26. Gress A., Smarsly B., Schlaad H.: Macromol. Rapid. Commun. 2008, 29, 304.

27. Gress A., Heilig A., Smarsly B., Heydenreich M., Schlaad H.: Macromolecules 2009, 42, 4244.

28. Hordyjewicz-Baran Z., You L., Smarsly B., Sigel R., Schlaad H.: Macromolecules 2007, 40, 3901.

29. Ahmad E., Naeem A., Javed S., Yadav S., Khan R. H.: J. Biochem. 2007, 142, 307.

30. Pieters R. J.: Org. Biomol. Chem. 2009, 7, 2013.

31. Ponader D., Wojcik F., Beceren-Braun F., Dernedde J., Hartmann L.: Biomacromolecules 2012, 13, 1845.

32. Spain S. G., Cameron N. R.: Polym. Chem. 2011, 2, 1552.

Google Scholar

Altmetric indicators

Citing articles via

Statistics

Total abstract views : 0

PDF Downloads : 0

C. Diehl polimery@ichp.pl

Affiliation
Max Planck Institute of Colloids and Interfaces Department of Colloid Chemistry, Research Campus Golm 14424 Potsdam, Germany

H. Schlaad

Affiliation
Max Planck Institute of Colloids and Interfaces Department of Colloid Chemistry, Research Campus Golm 14424 Potsdam, Germany