Język Polski
English
Synthesis and characterizations of poly hydroxybenzyl methacrylate-co-acrylamide based hydrogel as drug delivery system
Abstract
The aromatic/hydrophilic monomer, hydroxybenzyl methacrylate (HBM), was synthesized by reaction of 4-hydroxy benzyl alcohol with acrylic acid and then copolymerized with acrylamide (AAM) in various proportions. Potassium persulfate (PPS) was used as the initiator. The copolymer (3HBM/1AAM), selected based on the swelling results in water, was crosslinked using different concentrations of ethylene glycol dimethyl acrylate (EGDMA). The chemical structure of the monomer and copolymers was confirmed by Fourier transform infrared spectroscopy (FT-IR) and proton magnetic resonance (1H-NMR). The effect of the crosslinker concentration on the swelling, mechanical and thermal properties of the copolymers was investigated. The equilibrium water content (EWC) increased with the increase in the amount of crosslinker. The mechanical and thermal properties were also improved. The ability of the obtained copolymers to incorporate and release the drug (ciprofloxacin) was investigated based on swelling in the drug solution. A higher proportion of HBM in the copolymer resulted in a higher efficiency of the copolymer as a drug carrier.
Similar Articles
- Sandra Paszkiewicz, Grzegorz Kramek, Konrad Walkowiak, Izabela Irska, Elżbieta Piesowicz, Monika Rzonsowska, Beata Dudziec, Mateusz Barczewski, Thermal and mechanical properties of PLA/ENR thermoplastic vulcanizates compatibilized with tetrafunctional double-decker silsesquioxanes , Polimery: Vol. 68 No. 11-12 (2023)
- Paweł Stabla, Michał Smolnicki, Szymon Duda, Paweł Zielonka, Karolina Paczkowska, Zuzanna Pacholec, Michał Barcikowski, Wojciech Błażejewski, Influence of mosaic patterns in filament-wound tubes on mechanical behaviour under axial compression loading , Polimery: Vol. 69 No. 11-12 (2024)
- Jinyong Sui, zhengu, Xiaoyi Zhang, Zhenxu Li, Lining Song, Lina Yang, Ning Wang, Effects of carbon nanotubes and graphene on the structure and properties of natural rubber , Polimery: Vol. 66 No. 4 (2021)
- S. Ravichandran, A. Daniel Raj, P. Balaji Visvanath, Faruq Mohammad, Hamad A. Al-Lohedan, Suresh Sagadevan, Influence of fiber reinforcement towards the physical characteristics of low density polyethylene laminated composites , Polimery: Vol. 65 No. 6 (2020)
- Kailasam Chandrasekaran, Periyasamy Shanmugam , Palanisamy Senthilkumar, Mechanical and thermal properties of cotton-bamboo fabric/glass fiber epoxy composites , Polimery: Vol. 67 No. 11-12 (2022)
- Paweł Turek, Anna Bazan, Grzegorz Budzik, Łukasz Przeszłowski, Bartosz Gapiński, Surface roughness of photoacrylic resin shapes obtained using PolyJet additive technology , Polimery: Vol. 68 No. 11-12 (2023)
- Anandha Moorthy Appusamy, Natarajan Nanjappan, Prakash Eswaran, Madheswaran Subramanian, The effect of natural Gongura roselle fiber on the mechanical properties of 3D printed ABS and PLA composites , Polimery: Vol. 67 No. 3 (2022)
- M. Barczewski, M. Szostak, D. Nowak, A. Piasecki, Effect of wood flour addition and modification of its surface on the properties of rotationally molded polypropylene composites , Polimery: Vol. 63 No. 11-12 (2018)
- Karolina Młynarczyk, Filip Longwic, Beata Podkościelna, Tomasz Klepka, Influence of natural fillers on the thermal and mechanical properties of epoxy resin composites , Polimery: Vol. 67 No. 3 (2022)
- tomaszdziubek, Grzegorz Budzik, Andrzej Kawalec, Mariusz Dębski, Paweł Turek, Mariusz Oleksy, Andrzej Paszkiewicz, Przemysław Poliński, Łukasz Kochmański, Mateusz Kiełbicki, Jerzy Józwik, Ivan Kuric, Józef Cebulski, Strength of threaded connections additively produced from polymeric materials , Polimery: Vol. 67 No. 6 (2022)
You may also start an advanced similarity search for this article.
Details
References
Statistics
Authors
Zasady cytowania
Licence
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
