Polimery wykazujące samoorganizację makrocząsteczek jako systemy kontrolowanego uwalniania leków

M. El Fray; J. Gajowy

Published : 2012-04-30

Vol. 57 No. 4 (2012)

Polymeric self-assemblies as drug delivery systems

M. El Fray J. Gajowy

Abstract

The paper is a literature review concerning the polymers capable of macromolecular self-assembly — an interesting group of materials possessing diverse properties, which found various, especially medical applications, as controlled release drug delivery systems. Spontaneous assembly of macromolecules in solutions leads to the formation of various structural forms such as micelles, micro/nanospheres or polymersomes, as a result of the presence of weak bonds and interactions, i.e. hydrogen bonds as well as van der Waals, electrostatic or hydrophobic interactions, between specific parts of macromolecules. Selected structural patterns formed by self-assembly of macromolecules in organic and aqueous solutions were presented. The polymers capable of forming self-assembled structures, methods of their synthesis as well as the examples of medical applications as drug delivery systems have been described.

Keywords

drug delivery systems ; samoorganizacja makrocząsteczek ; polimery blokowe ; micele ; polimerosomy ; nośniki leków macromolecular self-assembly ; block polymers ; micelles ; polymersomes ; drug delivery systems

Details

References

Statistics

Authors

Download files

PDF (Język Polski)

Zasady cytowania

El Fray, M., & Gajowy, J. (2012). Polymeric self-assemblies as drug delivery systems. Polimery, 57(4), 257–265. Retrieved from https://polimery.ichp.vot.pl/index.php/p/article/view/824

References

Kedar U., Phutane P., Shidhaye S., Kadam V.: Nanomedicine: NBM 2010, 6, 714.

2. Bae Y., Kataoka K.: Adv. Drug Deliv. Rev. 2009, 61, 768.

3. Yuan J., Li Y., Li X., Cheng S., Jiang L., Feng L., Fan Z.: Europ. Polym. J. 2003, 39, 767.

4. Allen C., Maysinger D., Eisenberg A.: Colloid Surf. B 1999, 16, 3.

5. Letchford K., Burt H.: Eur. J. Pharm. Biopharm. 2007, 65, 259.

6. Zhong Y., Bellamkonda R.: J. R. Soc. Interface 2008, 5, 957.

7. Branco M., Schneider P. J.: Acta Biomater. 2009, 5(3), 817.

8. Zhang S., Marini M. D., Hwang W., Santoso S.: Curr. Opin. Chem. Biol. 2002, 6(6), 865.

9. Chow D., Nunalee M. L., Lim D.W., Simnick A. J.: Mater. Sci. Eng. 2008, 62(4), 125.

10. Schmalz H., Knoll A., Muuer A. J., Abetz V.: Macromolecules 2002, 35, 10004.

11. Gaucher G., Dufresne M.-H., Sant P. V., Kang N.: J. Contr. Release. 2005, 109, 169.

12. Kopecek J.: Eur. J. Pharm. Sci. 2003, 20, 1.

13. Sobczak M., Olędzka E., Kołodziejski W. L., Kuźmicz R.: Polimery 2007, 52, 411.

14. Qiu L. Y., Bae Y. H.: Biomaterials 2007, 28, 4132.

15. Li J., Li X., Ni X., Wang X.: Biomaterials 2006, 27, 4132.

16. Xie Z., Guan H., Chen L., Tian H.: Polymer 2005, 46, 10 523.

17. Chen W., Wei H., Li S., Feng J.: Polymer 2008, 49, 3965.

18. Tian Z., Wang M., Zhang A., Feng Z.: Polymer 2008, 49, 446.

19. Otsuka H., Nagasaki Y., Kataoka K.: Colloid. Interface. Sci. 2001, 6, 3.

20. Arote R. B., Jere D., Jiang H., Kim Y.: Biomed. Mater. 2009, 4, 044102.

21. Ma P. X.: Adv. Drug Deliv. Rev. 2008, 60(2), 184.

22. Zheng Ch., Qiu L., Zhu K.: Polymer 2009, 50, 1173.

23. Nardin C., Bolikal D., Kohn J.: Langmuir 2004, 20, 11 721.

24. Sun J., Chen X., Guo J., Shi Q.: Polymer 2009, 50, 455.

25. Niece K. L., Czeisler C., Sahni V., Tysseling-Mattiace V.: Biomaterials 2008, 29(34), 4501.

26. Rapoport N.: Prog. Polym. Sci. 2007, 32, 962.

27. Taubert A., Napoli A., MeierW.: Curr. Opin. Chem. Biol. 2004, 8, 598.

28. Qu T., Wang A., Yuana J., Gao Q.: J. Colloid. Interface. Sci. 2009, 336, 865.

29. Deng Ch., Chen X., Yu H., Sun J.: Polymer 2007, 48, 139.

30. Kumar A., Sivakova S., Fox J. D., Green J. E.: J. Am. Chem. Soc. 2008, 130(4), 1466.

31. Cai G., Jiang H., Chen Z., Tu K.,Wang L.: Eur. Polym. J. 2009, 45, 1674.

32. Tyrrell Z. L., Shena Y., Radosz M.: Progr. Polym. Sci. 2010, 35, 1128.

33. Kakizawa Y., Harada A., Kataoka K.: Biomacromolecules 2001, 2, 491.

34. Sanson Ch., Schatz Ch., Le Meins J.-F., Soum A.: J. Control. Release. 2010, 147, 428.

35. Chen W., Meng F., Cheng R., Zhong Z.: J. Control. Release. 2010, 142, 40.

36. Pluta J., Karolewicz B.: Polimery w medycynie 2008, 1, 1.

37. Utrata-Weso³ek A., Trzebicka B., Dworak A.: Polimery 2008, 53, 717.

Google Scholar

Citing articles via

Statistics

Total abstract views : 0

PDF Downloads : 0